In the past twenty years hundreds of infants and young children have died after being left in vehicles, usually by accident. When turning the vehicle off, drivers of the M5 are reminded to check the back seat if they opened the rear door before starting out. The Giulia Quadrifoglio doesn’t offer a back seat reminder.
The M5 has standard PostCrash iBrake, which automatically apply the brakes in the event of a crash to help prevent secondary collisions and prevent further injuries. The Giulia Quadrifoglio doesn’t offer a post collision braking system: in the event of a collision that triggers the airbags, more collisions are possible without the protection of airbags that may have already deployed.
Over 200 people are killed each year when backed over by motor vehicles. The M5 has standard Active Park Distance Control that uses rear sensors to monitor for objects to the rear and automatically applies the brakes to prevent a collision. The Giulia Quadrifoglio doesn’t offer backup collision prevention brakes.
The M5 has all-wheel drive to maximize traction under poor conditions, especially in ice and snow. The Giulia Quadrifoglio doesn’t offer all-wheel drive.
Both the M5 and the Giulia Quadrifoglio have standard driver and passenger frontal airbags, front side-impact airbags, driver and front passenger knee airbags, side-impact head airbags, front seatbelt pretensioners, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, lane departure warning systems, blind spot warning systems, rearview cameras and rear cross-path warning.
The BMW M5 weighs 1570 to 1710 pounds more than the Alfa Romeo Giulia Quadrifoglio. The NHTSA advises that heavier cars are much safer in collisions than their significantly lighter counterparts.

